bombay phenotype造句

• :: : Some other weird aberrations include the Bombay phenotype and random deletions.
• In addition to the A and B antigens, there are rare variations which can further complicate transfusions, such as the Bombay phenotype.
• Therefore, people with Bombay phenotype can receive blood only from other " hh " donors ( although they can donate as though they were type O ).
• (" Caution : ABO inheritance is generally derived assuming the children are not the very rare Bombay phenotype which would require both parents to be carriers of it . ")
• Occasionally, the blood types of children are not consistent with expectations for example, a type O child can be born to an AB parent due to rare situations, such as Bombay phenotype and cis AB.
• One exception is individuals with hh antigen system ( also known as the Bombay phenotype ) who can only receive blood safely from other hh donors, because they form antibodies against the H antigen present on all red blood cells.
• The vast majority of humans express H-substance, which is the basis for the ABO blood group system, but a few rare individuals ( " Bombay phenotype " ) do not and a chemical isolated from " Ulex europaeus " is used to identify these individuals.
• Production of the H antigen, or its deficiency in the Bombay phenotype, is controlled at the H locus on chromosome 19 . The H locus is not the same gene as the ABO locus, but it is epistatic to the ABO locus, providing the substrate for the A and B alleles to modify.
• For this reason people who have Bombay phenotype can donate red blood cells to any member of the ABO blood group system ( unless some other blood factor gene, such as Rhesus, is incompatible ), but they cannot receive blood from any member of the ABO blood group system ( which always contains one or more of A and B and H antigens ), but only from other people who have Bombay phenotype.
• For this reason people who have Bombay phenotype can donate red blood cells to any member of the ABO blood group system ( unless some other blood factor gene, such as Rhesus, is incompatible ), but they cannot receive blood from any member of the ABO blood group system ( which always contains one or more of A and B and H antigens ), but only from other people who have Bombay phenotype.
• Individuals with the rare Bombay phenotype ( hh ) do not express H antigen ( also called substance H ), the antigen which is present in blood group O . As a result, they cannot make A antigen ( also called substance A ) or B antigen ( substance B ) on their red blood cells, whatever alleles they may have of the A and B blood-group genes, because A antigen and B antigen are made from H antigen.